UNLOAD Study Results
UNLOAD
UltrafiltratioN versus IV Diuretics for Patients
HospitaLized fOr Acute
Decompensated Congestive
Heart Failure

The UNLOAD study was a randomized, multicenter study of 200 patients involving 28 hospitals and medical centers across the United States. UNLOAD compared the short and long-term safety and efficacy of an advanced form of ultrafiltration therapy(Aquapheresis) to the use of conventional diuretic drug therapy in fluid overloaded heart failure patients.

The UNLOAD study was published in the February 13, 2007 issue of Journal of American College of Cardiology. (Costanzo MR et al. JACC 2007; 49(6):675-683).

To receive a free reprint of the UNLOAD study and editorial published in JACC, along with the UNLOAD PowerPoint presentation, click here.

To listen and view the JACC Journal Club interview with the principal investigator of UNLOAD, click here.

At 48 hours into treatment, the ultrafiltration group
demonstrated over standard care a:
38% greater
weight loss
(p=0.001)
28% greater
net fluid loss
(p=0.001)
Equal improvement in dyspnea score
(p=0.35)
       
At 90 days following hospital discharge, the ultrafiltration
group demonstrated over standard care a:
43% reduction in patients requiring re-hospitalizations for heart failure
(p=0.037)
50% reduction in the total number of re-hospitalizations for heart failure
(p=0.022)
52% reduction in emergency department or clinic visits
(p=0.009)
63% reduction in total days re-hospitalized for heart failure
(p=0.022)
   
 
 

 

This site sponsored by CHF Solutions, Inc. Click here to learn more
about Aquapheresis® Therapy using Aquadex FlexFlow®.
 
L5142 Rev.A 01/07